Charité coordinates largest study in the world against common childhood cancer

Under an EU project now launched, Charité - Universitätsmedizin Berlin is coordinating the largest study in the world concerned with the fight against the most common type of cancer in children, acute lymphoblastic leukemia (ALL). Within the scope of the IntReALL project (Study for Children with Relapsed ALL) relapses (recurrences) are being researched in cases where ALL has already been treated, so that more young patients can be permanently cured. ALL relapse is the most common cause of death among children suffering from cancer. While for new cases of this type of leukemia the chances of survival have risen considerably over the past three decades, the outlook for young patients with a relapse is far worse.

The aim of IntReALL is to develop an optimized, internationally valid standard therapy for children with ALL relapse. Based on this best possible standard therapy the researchers plan to test a series of new substances with regard to their efficacy in this group of patients.

In Germany, acute lymphoblastic leukemia affects about 500 children and young persons a year, of whom about 70 on average suffer a relapse. The fact that ALL is so rare makes it more difficult to conduct comprehensive studies. This is where the international large-scale project, IntReALL, begins: A total of 23 mainly European partners - including clinics and companies - will be cooperating in the development of an optimized standard therapy, coordinated by Charité.