Grape seed extract (GSE) may help to kill head and neck cancer cells,
while leaving the healthy ones intact, according to a study by an Indian
origin scientist and his team.
It's a rather dramatic effect," said Rajesh Agarwal, PhD, investigator
at the University of Colorado Cancer Center and professor at the Skaggs
School of Pharmaceutical Sciences. It depends in large part on a healthy cell's ability to wait out damage, stated Agarwal. "Cancer cells are fast-growing cells. Not only that, but they are
necessarily fast growing. When conditions exist in which they can't
grow, they die," he explained.
Grape seed extract creates these conditions that are unfavorable to growth. Specifically, the study found that grape seed extract both damages
cancer cells' DNA (via increased reactive oxygen species) and stops the
pathways that allow repair (as seen by decreased levels of the DNA
repair molecules Brca1 and Rad51 and DNA repair foci)."Yet we saw absolutely no toxicity to the mice, themselves," said Agarwal.
Again, the grape seed extract killed the cancer cells but not the healthy cells.
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